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Systems-level conservation of the proximal TCR signaling network of mice and humans

We exploited traceable gene tagging in primary human T cells to establish the composition and dynamics of seven canonical TCR-induced protein signaling complexes (signalosomes) using affinity purification coupled with mass spectrometry (AP-MS). It unveiled how the LAT adaptor assembles higher-order...

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Detalles Bibliográficos
Autores principales:	Nicolas, Philippe, Ollier, Jocelyn, Mori, Daiki, Voisinne, Guillaume, Celis-Gutierrez, Javier, Gregoire, Claude, Perroteau, Jeanne, Vivien, Régine, Camus, Mylène, Burlet-Schiltz, Odile, Gonzalez de Peredo, Anne, Clémenceau, Béatrice, Roncagalli, Romain, Vié, Henri, Malissen, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Technical Advances and Resources
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789201/ https://www.ncbi.nlm.nih.gov/pubmed/35061003 http://dx.doi.org/10.1084/jem.20211295

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