Trypsin enhances SARS-CoV-2 infection by facilitating viral entry

Coronaviruses infect cells by cytoplasmic or endosomal membrane fusion, driven by the spike (S) protein, which must be primed by proteolytic cleavage at the S1/S2 furin cleavage site (FCS) and the S2′ site by cellular proteases. Exogenous trypsin as a medium additive facilitates isolation and propag...

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Detalles Bibliográficos
Autores principales: Kim, Yeeun, Jang, Guehwan, Lee, Duri, Kim, Nara, Seon, Jeong Won, Kim, Young-hoan, Lee, Changhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789370/
https://www.ncbi.nlm.nih.gov/pubmed/35079901
http://dx.doi.org/10.1007/s00705-021-05343-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789370/
https://www.ncbi.nlm.nih.gov/pubmed/35079901
http://dx.doi.org/10.1007/s00705-021-05343-0

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