Programmable siRNA pro-drugs that activate RNAi activity in response to specific cellular RNA biomarkers

Since Paul Ehrlich’s introduction of the “magic bullet” concept in 1908, drug developers have been seeking new ways to target drug activity to diseased cells while limiting effects on normal tissues. In recent years, it has been proposed that coupling riboswitches capable of detecting RNA biomarkers...

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Detalles Bibliográficos
Autores principales: Han, Si-ping, Scherer, Lisa, Gethers, Matt, Salvador, Ane M., Salah, Marwa Ben Haj, Mancusi, Rebecca, Sagar, Sahil, Hu, Robin, DeRogatis, Julia, Kuo, Ya-Huei, Marcucci, Guido, Das, Saumya, Rossi, John J., Goddard, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789579/
https://www.ncbi.nlm.nih.gov/pubmed/35116191
http://dx.doi.org/10.1016/j.omtn.2021.12.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789579/
https://www.ncbi.nlm.nih.gov/pubmed/35116191
http://dx.doi.org/10.1016/j.omtn.2021.12.039

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