Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

RAF kinases are essential effectors of RAS, but how RAS binding initiates the conformational changes needed for autoinhibited RAF monomers to form active dimers has remained unclear. Here, we present cryo-electron microscopy structures of full-length BRAF complexes derived from mammalian cells: auto...

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Detalles Bibliográficos
Autores principales: Martinez Fiesco, Juliana A., Durrant, David E., Morrison, Deborah K., Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789793/
https://www.ncbi.nlm.nih.gov/pubmed/35078985
http://dx.doi.org/10.1038/s41467-022-28084-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789793/
https://www.ncbi.nlm.nih.gov/pubmed/35078985
http://dx.doi.org/10.1038/s41467-022-28084-3

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