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Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens
N(6)-methyladenosine (m(6)A) plays important role in lineage specifications of embryonic stem cells. However, it is still difficult to systematically dissect the specific m(6)A sites that are essential for early lineage differentiation. Here, we develop an adenine base editor-based strategy to syste...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789821/ https://www.ncbi.nlm.nih.gov/pubmed/35078991 http://dx.doi.org/10.1038/s41467-022-28106-0 |