Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

Signaling-biased ligands acting on G-protein-coupled receptors (GPCRs) differentially activate heterotrimeric G proteins and β-arrestins. Although a wealth of structural knowledge about signaling bias at the GPCR level exists (preferential engagement of a specific transducer), little is known about...

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Detalles Bibliográficos
Autores principales: Kawakami, Kouki, Yanagawa, Masataka, Hiratsuka, Suzune, Yoshida, Misaki, Ono, Yuki, Hiroshima, Michio, Ueda, Masahiro, Aoki, Junken, Sako, Yasushi, Inoue, Asuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789823/
https://www.ncbi.nlm.nih.gov/pubmed/35078997
http://dx.doi.org/10.1038/s41467-022-28056-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789823/
https://www.ncbi.nlm.nih.gov/pubmed/35078997
http://dx.doi.org/10.1038/s41467-022-28056-7

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