Cargando…

Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

Signaling-biased ligands acting on G-protein-coupled receptors (GPCRs) differentially activate heterotrimeric G proteins and β-arrestins. Although a wealth of structural knowledge about signaling bias at the GPCR level exists (preferential engagement of a specific transducer), little is known about...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawakami, Kouki, Yanagawa, Masataka, Hiratsuka, Suzune, Yoshida, Misaki, Ono, Yuki, Hiroshima, Michio, Ueda, Masahiro, Aoki, Junken, Sako, Yasushi, Inoue, Asuka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789823/ https://www.ncbi.nlm.nih.gov/pubmed/35078997 http://dx.doi.org/10.1038/s41467-022-28056-7

Ejemplares similares

Real-time visualization of heterotrimeric G protein Gq activation in living cells
por: Adjobo-Hermans, Merel JW, et al.
Publicado: (2011)

Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs
por: Ono, Yuki, et al.
Publicado: (2023)

Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells
por: Kuwashima, Yutaro, et al.
Publicado: (2021)

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
por: Erickson, Catherine E., et al.
Publicado: (2013)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Direct coupling of detergent purified human mGlu(5) receptor to the heterotrimeric G proteins Gq and Gs
por: Nasrallah, Chady, et al.
Publicado: (2018)

Double life: How GRK2 and β-arrestin signaling participate in diseases
por: Zhai, Ruxu, et al.
Publicado: (2022)

CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2
por: Nguyen, Huong Thi, et al.
Publicado: (2020)

Lack of beta-arrestin signaling in the absence of active G proteins
por: Grundmann, Manuel, et al.
Publicado: (2018)

ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment
por: Sánchez-Fernández, Guzmán, et al.
Publicado: (2013)

ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding
por: Chen, Qiuyan, et al.
Publicado: (2023)

Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
por: Tatsumi, Manae, et al.
Publicado: (2023)

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
por: Zhang, Dao-Lai, et al.
Publicado: (2018)

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor
por: Burghi, Valeria, et al.
Publicado: (2023)

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
por: Møller, Thor C., et al.
Publicado: (2020)

Isoprenaline and salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2
por: Ajmal, Iqra, et al.
Publicado: (2022)

Disentangling bias between G(q), GRK2, and arrestin3 recruitment to the M(3) muscarinic acetylcholine receptor
por: Flöser, Anja, et al.
Publicado: (2021)

Carbetocin is a Functional Selective Gq Agonist That Does Not Promote Oxytocin Receptor Recycling After Inducing β‐Arrestin‐Independent Internalisation
por: Passoni, I., et al.
Publicado: (2016)

Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
por: Janetzko, John, et al.
Publicado: (2022)

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells
por: Lowther, Katie M., et al.
Publicado: (2013)

Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases
por: Liu, Haiping, et al.
Publicado: (2023)

The experimental power of FR900359 to study Gq-regulated biological processes
por: Schrage, Ramona, et al.
Publicado: (2015)

Automated single-molecule imaging in living cells
por: Yasui, Masato, et al.
Publicado: (2018)

The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively
por: Al-Sabah, Suleiman, et al.
Publicado: (2014)

Effects of the Dopamine D2 Allosteric Modulator, PAOPA, on the Expression of GRK2, Arrestin-3, ERK1/2, and on Receptor Internalization
por: Basu, Dipannita, et al.
Publicado: (2013)

Gq-Coupled Receptors in Autoimmunity
por: Zhang, Lu, et al.
Publicado: (2016)

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface
por: Heo, Yunseok, et al.
Publicado: (2022)

β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
por: Woo, Jung-AA, et al.
Publicado: (2021)

Class B1 GPCR activation by an intracellular agonist
por: Kobayashi, Kazuhiro, et al.
Publicado: (2023)

Single-molecule fluorescence-based analysis of protein conformation, interaction, and oligomerization in cellular systems
por: Okamoto, Kenji, et al.
Publicado: (2017)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
por: Reichel, Mona, et al.
Publicado: (2022)

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides
por: Dai, Shizhong A., et al.
Publicado: (2022)

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor
por: McCormick, Peter J., et al.
Publicado: (2009)

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias
por: Sergeev, Eugenia, et al.
Publicado: (2017)

An experimental strategy to probe Gq contribution to signal transduction in living cells
por: Patt, Julian, et al.
Publicado: (2021)

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
por: Pandey, Shubhi, et al.
Publicado: (2021)

Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020)

Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells
por: Kamimura, Yoichiro, et al.
Publicado: (2021)

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
por: Baidya, Mithu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_oq6jpli922b0jbapsa5tubbjrm