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Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells
The cerebral cortex is formed by diverse neurons generated sequentially from neural stem cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression of NSCs, which is mainly defined by the transcriptome and the epigenetic state. However, what drives such a developmental c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789897/ https://www.ncbi.nlm.nih.gov/pubmed/35078993 http://dx.doi.org/10.1038/s41467-022-28097-y |
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author | Wu, Quan Shichino, Yuichi Abe, Takaya Suetsugu, Taeko Omori, Ayaka Kiyonari, Hiroshi Iwasaki, Shintaro Matsuzaki, Fumio |
author_facet | Wu, Quan Shichino, Yuichi Abe, Takaya Suetsugu, Taeko Omori, Ayaka Kiyonari, Hiroshi Iwasaki, Shintaro Matsuzaki, Fumio |
author_sort | Wu, Quan |
collection | PubMed |
description | The cerebral cortex is formed by diverse neurons generated sequentially from neural stem cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression of NSCs, which is mainly defined by the transcriptome and the epigenetic state. However, what drives such a developmental clock remains elusive. We show that translational control of histone H3 trimethylation in Lys27 (H3K27me3) modifiers is part of this clock. We find that depletion of Fbl, an rRNA methyltransferase, reduces translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3K27me3 and delays the progression of the NSC state. These defects are partially phenocopied by simultaneous inhibition of H3K27me3 methyltransferase and demethylase, indicating the role of Fbl in the genome-wide H3K27me3 pattern. Therefore, we propose that Fbl drives the intrinsic clock through the translational enhancement of the H3K27me3 modifiers that predominantly define the NSC state. |
format | Online Article Text |
id | pubmed-8789897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87898972022-02-07 Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells Wu, Quan Shichino, Yuichi Abe, Takaya Suetsugu, Taeko Omori, Ayaka Kiyonari, Hiroshi Iwasaki, Shintaro Matsuzaki, Fumio Nat Commun Article The cerebral cortex is formed by diverse neurons generated sequentially from neural stem cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression of NSCs, which is mainly defined by the transcriptome and the epigenetic state. However, what drives such a developmental clock remains elusive. We show that translational control of histone H3 trimethylation in Lys27 (H3K27me3) modifiers is part of this clock. We find that depletion of Fbl, an rRNA methyltransferase, reduces translation of both Ezh2 methyltransferase and Kdm6b demethylase of H3K27me3 and delays the progression of the NSC state. These defects are partially phenocopied by simultaneous inhibition of H3K27me3 methyltransferase and demethylase, indicating the role of Fbl in the genome-wide H3K27me3 pattern. Therefore, we propose that Fbl drives the intrinsic clock through the translational enhancement of the H3K27me3 modifiers that predominantly define the NSC state. Nature Publishing Group UK 2022-01-25 /pmc/articles/PMC8789897/ /pubmed/35078993 http://dx.doi.org/10.1038/s41467-022-28097-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wu, Quan Shichino, Yuichi Abe, Takaya Suetsugu, Taeko Omori, Ayaka Kiyonari, Hiroshi Iwasaki, Shintaro Matsuzaki, Fumio Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title | Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title_full | Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title_fullStr | Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title_full_unstemmed | Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title_short | Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
title_sort | selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789897/ https://www.ncbi.nlm.nih.gov/pubmed/35078993 http://dx.doi.org/10.1038/s41467-022-28097-y |
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