Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers. The use of metformin in hematologic cancers has...

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Detalles Bibliográficos
Autores principales: Allende-Vega, Nerea, Marco Brualla, Joaquin, Falvo, Paolo, Alexia, Catherine, Constantinides, Michael, de Maudave, Alexis Fayd’herbe, Coenon, Lois, Gitenay, Delphine, Mitola, Giulia, Massa, Paul, Orecchioni, Stefania, Bertolini, Francesco, Marzo, Isabel, Anel, Alberto, Villalba, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789909/
https://www.ncbi.nlm.nih.gov/pubmed/35079096
http://dx.doi.org/10.1038/s41598-022-05470-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789909/
https://www.ncbi.nlm.nih.gov/pubmed/35079096
http://dx.doi.org/10.1038/s41598-022-05470-x

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