Microbial Cell Factory of Baccatin III Preparation in Escherichia coli by Increasing DBAT Thermostability and in vivo Acetyl-CoA Supply

Given the rapid development of genome mining in this decade, the substrate channel of paclitaxel might be identified in the near future. A robust microbial cell factory with gene dbat, encoding a key rate-limiting enzyme 10-deacetylbaccatin III-10-O-transferase (DBAT) in paclitaxel biosynthesis to s...

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Detalles Bibliográficos
Autores principales: Huang, Jia-jun, Wei, Tao, Ye, Zhi-wei, Zheng, Qian-wang, Jiang, Bing-hua, Han, Wen-feng, Ye, An-qi, Han, Pei-yun, Guo, Li-qiong, Lin, Jun-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790024/
https://www.ncbi.nlm.nih.gov/pubmed/35095813
http://dx.doi.org/10.3389/fmicb.2021.803490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790024/
https://www.ncbi.nlm.nih.gov/pubmed/35095813
http://dx.doi.org/10.3389/fmicb.2021.803490

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