Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency

Mitochondrial aspartate-glutamate carrier isoform 1 (AGC1) deficiency is an ultra-rare genetic disease characterized by global hypomyelination and brain atrophy, caused by mutations in the SLC25A12 gene leading to a reduction in AGC1 activity. In both neuronal precursor cells and oligodendrocytes pr...

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Detalles Bibliográficos
Autores principales: Poeta, Eleonora, Petralla, Sabrina, Babini, Giorgia, Renzi, Brunaldo, Celauro, Luigi, Magnifico, Maria Chiara, Barile, Simona Nicole, Masotti, Martina, De Chirico, Francesca, Massenzio, Francesca, Viggiano, Luigi, Palmieri, Luigi, Virgili, Marco, Lasorsa, Francesco Massimo, Monti, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790092/
https://www.ncbi.nlm.nih.gov/pubmed/35095421
http://dx.doi.org/10.3389/fncel.2021.773709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790092/
https://www.ncbi.nlm.nih.gov/pubmed/35095421
http://dx.doi.org/10.3389/fncel.2021.773709

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