Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1–Nup98 Complex to Compete With mRNA Nuclear Export

The accessory protein Orf6 is uniquely expressed in sarbecoviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is an ongoing pandemic. SARS-CoV-2 Orf6 antagonizes host interferon signaling by inhibition of mRNA nuclear export through its interactions with the ribonuc...

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Detalles Bibliográficos
Autores principales: Li, Tinghan, Wen, Yibo, Guo, Hangtian, Yang, Tingting, Yang, Haitao, Ji, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790125/
https://www.ncbi.nlm.nih.gov/pubmed/35096974
http://dx.doi.org/10.3389/fmolb.2021.813248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790125/
https://www.ncbi.nlm.nih.gov/pubmed/35096974
http://dx.doi.org/10.3389/fmolb.2021.813248

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