A Combined Chemical, Computational, and In Vitro Approach Identifies SBL-105 as Novel DHODH Inhibitor in Acute Myeloid Leukemia Cells

Inhibition of the dihydroorotate dehydrogenase (DHODH) has been successful at the preclinical level in controlling myeloid leukemia. However, poor clinical trials warrant the search for new potent DHODH inhibitors. Herein we present a novel DHODH inhibitor SBL-105 effective against myeloid leukemia....

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Detalles Bibliográficos
Autores principales: Kamli, Hossam, Zaman, Gaffar S., Shaikh, Ahmad, Mobarki, Abdullah A., Rajagopalan, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790134/
https://www.ncbi.nlm.nih.gov/pubmed/34353411
http://dx.doi.org/10.3727/096504021X16281573507558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790134/
https://www.ncbi.nlm.nih.gov/pubmed/34353411
http://dx.doi.org/10.3727/096504021X16281573507558

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