Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory disease that manifests as a preclinical stage of systemic autoimmunity followed by chronic progressive synovitis. Disease-associated genetic SNP variants predominantly map to non-coding, regulatory regions of functional importance in CD4 T cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Jadhav, Rohit R., Hu, Bin, Ye, Zhongde, Sheth, Khushboo, Li, Xuanying, Greenleaf, William J., Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790491/
https://www.ncbi.nlm.nih.gov/pubmed/35085847
http://dx.doi.org/10.1016/j.ebiom.2022.103825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790491/
https://www.ncbi.nlm.nih.gov/pubmed/35085847
http://dx.doi.org/10.1016/j.ebiom.2022.103825

Ejemplares similares