Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET

Interleukin-23 (IL-23) is a pro-inflammatory cytokine involved in the host defense against pathogens but is also implicated in the development of several autoimmune disorders. The IL-23 receptor has become a key target for drug discovery, but the exact mechanism of the receptor ligand interaction re...

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Detalles Bibliográficos
Autores principales: Lay, Charles S., Bridges, Angela, Goulding, Joelle, Briddon, Stephen J., Soloviev, Zoja, Craggs, Peter D., Hill, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790524/
https://www.ncbi.nlm.nih.gov/pubmed/34038748
http://dx.doi.org/10.1016/j.chembiol.2021.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790524/
https://www.ncbi.nlm.nih.gov/pubmed/34038748
http://dx.doi.org/10.1016/j.chembiol.2021.05.002

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