CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data

We introduce CellPhy, a maximum likelihood framework for inferring phylogenetic trees from somatic single-cell single-nucleotide variants. CellPhy leverages a finite-site Markov genotype model with 16 diploid states and considers amplification error and allelic dropout. We implement CellPhy into RAx...

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Detalles Bibliográficos
Autores principales: Kozlov, Alexey, Alves, Joao M., Stamatakis, Alexandros, Posada, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790911/
https://www.ncbi.nlm.nih.gov/pubmed/35081992
http://dx.doi.org/10.1186/s13059-021-02583-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790911/
https://www.ncbi.nlm.nih.gov/pubmed/35081992
http://dx.doi.org/10.1186/s13059-021-02583-w

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