Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size

PURPOSE: Lipid nanoparticles (LNPs) are widely utilized as means to deliver mRNA molecules. However, metric connections between biodistribution and pharmacokinetics (PK) of the nanoparticle carrier and transgene expression dynamics remain largely unknown. METHODS: LNPs containing mRNAs encoding the...

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Detalles Bibliográficos
Autores principales: Di, Jiaxing, Du, Zhili, Wu, Kangzeng, Jin, Shanshan, Wang, Xun, Li, Tonglei, Xu, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791091/
https://www.ncbi.nlm.nih.gov/pubmed/35080707
http://dx.doi.org/10.1007/s11095-022-03166-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791091/
https://www.ncbi.nlm.nih.gov/pubmed/35080707
http://dx.doi.org/10.1007/s11095-022-03166-5

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