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Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size
PURPOSE: Lipid nanoparticles (LNPs) are widely utilized as means to deliver mRNA molecules. However, metric connections between biodistribution and pharmacokinetics (PK) of the nanoparticle carrier and transgene expression dynamics remain largely unknown. METHODS: LNPs containing mRNAs encoding the...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791091/ https://www.ncbi.nlm.nih.gov/pubmed/35080707 http://dx.doi.org/10.1007/s11095-022-03166-5 |