Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria

Endothelial defects significantly contribute to cardiovascular pathology in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium-specific progeria mouse model, we identify a novel, endothelium-specific microRNA (miR) signature linked to the p53-senescence pat...

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Detalles Bibliográficos
Autores principales: Manakanatas, Christina, Ghadge, Santhosh Kumar, Agic, Azra, Sarigol, Fatih, Fichtinger, Petra, Fischer, Irmgard, Foisner, Roland, Osmanagic-Myers, Selma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791216/
https://www.ncbi.nlm.nih.gov/pubmed/35020601
http://dx.doi.org/10.18632/aging.203820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791216/
https://www.ncbi.nlm.nih.gov/pubmed/35020601
http://dx.doi.org/10.18632/aging.203820

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