Chemical Evolution of Rhinovirus Identifies Capsid-Destabilizing Mutations Driving Low-pH-Independent Genome Uncoating

Rhinoviruses (RVs) cause recurrent infections of the nasal and pulmonary tracts, life-threatening conditions in chronic respiratory illness patients, predisposition of children to asthmatic exacerbation, and large economic cost. RVs are difficult to treat. They rapidly evolve resistance and are gene...

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Detalles Bibliográficos
Autores principales: Murer, Luca, Petkidis, Anthony, Vallet, Thomas, Vignuzzi, Marco, Greber, Urs F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791267/
https://www.ncbi.nlm.nih.gov/pubmed/34705560
http://dx.doi.org/10.1128/JVI.01060-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791267/
https://www.ncbi.nlm.nih.gov/pubmed/34705560
http://dx.doi.org/10.1128/JVI.01060-21

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