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Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery

Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochondrial protein import machinery cause human pathologies. However, a lack of suitable tools to measure protein uptake across the mitochondrial proteome has prevented the identification of...

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Detalles Bibliográficos
Autores principales: Schäfer, Jasmin Adriana, Bozkurt, Süleyman, Michaelis, Jonas Benjamin, Klann, Kevin, Münch, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791276/
https://www.ncbi.nlm.nih.gov/pubmed/34847359
http://dx.doi.org/10.1016/j.molcel.2021.11.004