Toll-like receptor 4 selective inhibition in medullar microenvironment alters multiple myeloma cell growth

Bone marrow (BM) mesenchymal stromal cells (MSCs) are abnormal in multiple myeloma (MM) and play a critical role by promoting growth, survival, and drug resistance of MM cells. We observed higher Toll-like receptor 4 (TLR4) gene expression in MM MSCs than in MSCs from healthy donors. At the clinical...

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Detalles Bibliográficos
Autores principales: Lemaitre, Léa, Hamaidia, Malik, Descamps, Jean-Gérard, Do Souto Ferreira, Laura, Joubert, Marie-Véronique, Gadelorge, Mélanie, Avet-Loiseau, Hervé, Justo, Arthur, Reina, Nicolas, Deschaseaux, Frederic, Martinet, Ludovic, Bourin, Philippe, Corre, Jill, Espagnolle, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791574/
https://www.ncbi.nlm.nih.gov/pubmed/34714910
http://dx.doi.org/10.1182/bloodadvances.2020003704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791574/
https://www.ncbi.nlm.nih.gov/pubmed/34714910
http://dx.doi.org/10.1182/bloodadvances.2020003704

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