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Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival
Multiple myeloma (MM) cells suffer from baseline proteotoxicity as the result of an imbalance between the load of misfolded proteins awaiting proteolysis and the capacity of the ubiquitin-proteasome system to degrade them. This intrinsic vulnerability is at the base of MM sensitivity to agents that...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791580/ https://www.ncbi.nlm.nih.gov/pubmed/34649278 http://dx.doi.org/10.1182/bloodadvances.2020003820 |