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Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival

Multiple myeloma (MM) cells suffer from baseline proteotoxicity as the result of an imbalance between the load of misfolded proteins awaiting proteolysis and the capacity of the ubiquitin-proteasome system to degrade them. This intrinsic vulnerability is at the base of MM sensitivity to agents that...

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Detalles Bibliográficos
Autores principales:	Chen, Tianzeng, Ho, Matthew, Briere, Jenna, Moscvin, Maria, Czarnecki, Peter G., Anderson, Kenneth C., Blackwell, T. Keith, Bianchi, Giada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Stimulus Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791580/ https://www.ncbi.nlm.nih.gov/pubmed/34649278 http://dx.doi.org/10.1182/bloodadvances.2020003820

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