Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

Cholesterol homeostasis has been proposed as one mechanism contributing to chemoresistance in AML and hence, inclusion of statins in therapeutic regimens as part of clinical trials in AML has shown encouraging results. Chemical screening of primary human AML specimens by our group led to the identif...

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Detalles Bibliográficos
Autores principales: Krosl, Jana, Bordeleau, Marie-Eve, Moison, Céline, MacRae, Tara, Boivin, Isabel, Mayotte, Nadine, Gracias, Deanne, Baccelli, Irène, Lavallée, Vincent-Philippe, Bisaillon, Richard, Lehnertz, Bernhard, Mendoza-Sanchez, Rodrigo, Ruel, Réjean, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Boucher, Geneviève, Noronha, Nandita, Pabst, Caroline, Tyers, Mike, Gendron, Patrick, Lemieux, Sébastien, Barabé, Frédéric, Marinier, Anne, Hébert, Josée, Sauvageau, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791584/
https://www.ncbi.nlm.nih.gov/pubmed/34731885
http://dx.doi.org/10.1182/bloodadvances.2021006047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791584/
https://www.ncbi.nlm.nih.gov/pubmed/34731885
http://dx.doi.org/10.1182/bloodadvances.2021006047

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