Predicting bacterial promoter function and evolution from random sequences

Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we developed a biophysical model that accounts for multipl...

Descripción completa

Detalles Bibliográficos
Autores principales: Lagator, Mato, Sarikas, Srdjan, Steinrueck, Magdalena, Toledo-Aparicio, David, Bollback, Jonathan P, Guet, Calin C, Tkačik, Gašper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791639/
https://www.ncbi.nlm.nih.gov/pubmed/35080492
http://dx.doi.org/10.7554/eLife.64543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791639/
https://www.ncbi.nlm.nih.gov/pubmed/35080492
http://dx.doi.org/10.7554/eLife.64543

Ejemplares similares