Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has a central role in non-homologous end joining, one of the two main pathways that detect and repair DNA double-strand breaks (DSBs) in humans(1,2). DNA-PKcs is of great importance in repairing pathological DSBs, making DNA-PKcs inhibito...

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Detalles Bibliográficos
Autores principales: Liang, Shikang, Thomas, Sherine E., Chaplin, Amanda K., Hardwick, Steven W., Chirgadze, Dimitri Y., Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791830/
https://www.ncbi.nlm.nih.gov/pubmed/34987222
http://dx.doi.org/10.1038/s41586-021-04274-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791830/
https://www.ncbi.nlm.nih.gov/pubmed/34987222
http://dx.doi.org/10.1038/s41586-021-04274-9

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