Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

The modular organization of the type I polyketide synthases (PKSs) would seem propitious for rational engineering of desirable analogous. However, despite decades of efforts, such experiments remain largely inefficient. Here, we combine multiple, state-of-the-art approaches to reprogram the stambomy...

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Detalles Bibliográficos
Autores principales: Su, Li, Hôtel, Laurence, Paris, Cédric, Chepkirui, Clara, Brachmann, Alexander O., Piel, Jörn, Jacob, Christophe, Aigle, Bertrand, Weissman, Kira J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792006/
https://www.ncbi.nlm.nih.gov/pubmed/35082289
http://dx.doi.org/10.1038/s41467-022-27955-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792006/
https://www.ncbi.nlm.nih.gov/pubmed/35082289
http://dx.doi.org/10.1038/s41467-022-27955-z

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