JAK2 inhibitor persistence in MPN: uncovering a central role of ERK activation

The Philadelphia chromosome negative myeloproliferative neoplasms, including polycythemia vera, essential thrombocytosis, and myelofibrosis, are driven by hyper activation of the JAK2 tyrosine kinase, the result of mutations in three MPN driving genes: JAK2, MPL, and CALR. While the anti-inflammator...

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Detalles Bibliográficos
Autores principales: Pandey, Garima, Kuykendall, Andrew T., Reuther, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792018/
https://www.ncbi.nlm.nih.gov/pubmed/35082276
http://dx.doi.org/10.1038/s41408-022-00609-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792018/
https://www.ncbi.nlm.nih.gov/pubmed/35082276
http://dx.doi.org/10.1038/s41408-022-00609-5

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