Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38(+) macrophages and NAD(+) decline

As we age, our body experiences chronic, systemic inflammation contributing to the morbidity and mortality of the elderly. The senescent immune system has been described to have a causal role in driving systemic aging and therefore may represent a key therapeutic target to prevent pathological conse...

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Detalles Bibliográficos
Autores principales: Ciaglia, Elena, Lopardo, Valentina, Montella, Francesco, Carrizzo, Albino, Di Pietro, Paola, Malavolta, Marco, Giacconi, Robertina, Orlando, Fiorenza, Cattaneo, Monica, Madeddu, Paolo, Vecchione, Carmine, Puca, Annibale Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792139/
https://www.ncbi.nlm.nih.gov/pubmed/35087020
http://dx.doi.org/10.1038/s41419-022-04535-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792139/
https://www.ncbi.nlm.nih.gov/pubmed/35087020
http://dx.doi.org/10.1038/s41419-022-04535-z

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