ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP

Metabolic adaptation and signal integration in response to hypoxic conditions is mainly regulated by hypoxia-inducible factors (HIFs). At the same time, hypoxia induces ROS formation and activates the unfolded protein response (UPR), indicative of endoplasmic reticulum (ER) stress. However, whether...

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Detalles Bibliográficos
Autores principales: Mennerich, Daniela, Kubaichuk, Kateryna, Raza, Ghulam S., Fuhrmann, Dominik C., Herzig, Karl-Heinz, Brüne, Bernhard, Kietzmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792260/
https://www.ncbi.nlm.nih.gov/pubmed/35074541
http://dx.doi.org/10.1016/j.redox.2022.102243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792260/
https://www.ncbi.nlm.nih.gov/pubmed/35074541
http://dx.doi.org/10.1016/j.redox.2022.102243

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