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ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP
Metabolic adaptation and signal integration in response to hypoxic conditions is mainly regulated by hypoxia-inducible factors (HIFs). At the same time, hypoxia induces ROS formation and activates the unfolded protein response (UPR), indicative of endoplasmic reticulum (ER) stress. However, whether...
Autores principales: | Mennerich, Daniela, Kubaichuk, Kateryna, Raza, Ghulam S., Fuhrmann, Dominik C., Herzig, Karl-Heinz, Brüne, Bernhard, Kietzmann, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792260/ https://www.ncbi.nlm.nih.gov/pubmed/35074541 http://dx.doi.org/10.1016/j.redox.2022.102243 |
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