BRD4‐IRF1 axis regulates chemoradiotherapy‐induced PD‐L1 expression and immune evasion in non‐small cell lung cancer

BACKGROUND: Chemoradiotherapy‐induced PD‐L1 upregulation leads to therapeutic resistance and treatment failure. The PD‐1/PD‐L1 blocking antibodies sensitize cancers to chemoradiotherapy by blocking extracellular PD‐1 and PD‐L1 binding without affecting the oncogenic function of intracellular PD‐L1....

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Detalles Bibliográficos
Autores principales: Wang, Jian, Xu, Yingzhuo, Rao, Xinrui, Zhang, Ruiguang, Tang, Jing, Zhang, Dan, Jie, Xiaohua, Zhu, Kuikui, Wang, Xu, Xu, Yunhong, Zhang, Sheng, Dong, Xiaorong, Zhang, Tao, Yang, Kunyu, Xu, Shuangbing, Meng, Rui, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792480/
https://www.ncbi.nlm.nih.gov/pubmed/35083874
http://dx.doi.org/10.1002/ctm2.718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792480/
https://www.ncbi.nlm.nih.gov/pubmed/35083874
http://dx.doi.org/10.1002/ctm2.718

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