B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

[Image: see text] Colchicine, the main active alkaloid from Colchicum autumnale L., is a potent tubulin binder and represents an interesting lead structure for the development of potential anticancer chemotherapeutics. We report on the synthesis and investigation of potentially reactive colchicinoid...

Descripción completa

Detalles Bibliográficos
Autores principales: Stein, Andreas, Hilken née Thomopoulou, Persefoni, Frias, Corazon, Hopff, Sina M., Varela, Paloma, Wilke, Nicola, Mariappan, Arul, Neudörfl, Jörg-Martin, Fedorov, Alexey Yu, Gopalakrishnan, Jay, Gigant, Benoît, Prokop, Aram, Schmalz, Hans-Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792921/
https://www.ncbi.nlm.nih.gov/pubmed/35097257
http://dx.doi.org/10.1021/acsomega.1c04659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792921/
https://www.ncbi.nlm.nih.gov/pubmed/35097257
http://dx.doi.org/10.1021/acsomega.1c04659

Ejemplares similares