Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

[Image: see text] The dengue NS2B-NS3 protease existing in equilibrium between the active and inactive forms is essential for virus replication, thus representing a key drug target. Here, myricetin, a plant flavonoid, was characterized to noncompetitively inhibit the dengue protease. Further NMR stu...

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Detalles Bibliográficos
Autores principales: Dang, Mei, Lim, Liangzhong, Roy, Amrita, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793048/
https://www.ncbi.nlm.nih.gov/pubmed/35097276
http://dx.doi.org/10.1021/acsomega.1c05569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793048/
https://www.ncbi.nlm.nih.gov/pubmed/35097276
http://dx.doi.org/10.1021/acsomega.1c05569

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