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Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice

[Image: see text] Capsaicin, the compound in hot chili peppers responsible for their pungency and an agonist of the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), has long been known to promote the desensitization of nociceptors at high concentrations. This has led to th...

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Detalles Bibliográficos
Autores principales: Treat, Anny, Henri, Vianie, Liu, Junke, Shen, Joyce, Gil-Silva, Mauricio, Morales, Alejandro, Rade, Avaneesh, Tidgewell, Kevin Joseph, Kolber, Benedict, Shen, Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793056/
https://www.ncbi.nlm.nih.gov/pubmed/35097287
http://dx.doi.org/10.1021/acsomega.1c05727