The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

It is unclear whether SARS-CoV-2, which causes COVID-19, can enter the brain. SARS-CoV-2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier (BBB) in male mice, was taken up by brain regions and...

Descripción completa

Detalles Bibliográficos
Autores principales: Rhea, Elizabeth M., Logsdon, Aric F., Hansen, Kim M., Williams, Lindsey M., Reed, May J., Baumann, Kristen K., Holden, Sarah J., Raber, Jacob, Banks, William A., Erickson, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793077/
https://www.ncbi.nlm.nih.gov/pubmed/33328624
http://dx.doi.org/10.1038/s41593-020-00771-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793077/
https://www.ncbi.nlm.nih.gov/pubmed/33328624
http://dx.doi.org/10.1038/s41593-020-00771-8

Ejemplares similares