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The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

It is unclear whether SARS-CoV-2, which causes COVID-19, can enter the brain. SARS-CoV-2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier (BBB) in male mice, was taken up by brain regions and...

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Detalles Bibliográficos
Autores principales:	Rhea, Elizabeth M., Logsdon, Aric F., Hansen, Kim M., Williams, Lindsey M., Reed, May J., Baumann, Kristen K., Holden, Sarah J., Raber, Jacob, Banks, William A., Erickson, Michelle A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793077/ https://www.ncbi.nlm.nih.gov/pubmed/33328624 http://dx.doi.org/10.1038/s41593-020-00771-8

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