Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases

Cholangiocarcinoma (CCA) is a rare but highly aggressive tumor entity for which systemic therapies only showed limited efficacy so far. As OSI-027—a dual kinase inhibitor targeting both mTOR complexes, mTORC1 and mTORC2 - showed improved anti-cancer effects, we sought to evaluate its impact on the m...

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Detalles Bibliográficos
Autores principales: Joechle, Katharina, Jumaa, Huda, Thriene, Kerstin, Hellerbrand, Claus, Kulemann, Birte, Fichtner-Feigl, Stefan, Lang, Sven A., Guenzle, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793831/
https://www.ncbi.nlm.nih.gov/pubmed/35096817
http://dx.doi.org/10.3389/fcell.2021.785979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793831/
https://www.ncbi.nlm.nih.gov/pubmed/35096817
http://dx.doi.org/10.3389/fcell.2021.785979

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