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“Double-Hit” Chronic Lymphocytic Leukemia, Involving the TP53 and MYC Genes
Although the 17p deletion [del(17p)] is rare in cases of treatment-naive chronic lymphocytic leukemia (CLL), its frequency is higher in refractory/relapsed CLL – particularly in patients undergoing chemo(immuno)therapy. TP53 disruption (deletion and/or mutation) is the strongest prognostic factor fo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793848/ https://www.ncbi.nlm.nih.gov/pubmed/35096627 http://dx.doi.org/10.3389/fonc.2021.826245 |