Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity

A transframe region within HIV-1 Gag-Pol (referred to as p6* or p6pol), directly linked to the protease (PR) N-terminus, plays a pivotal role in modulating PR activation. To identify specific p6* residues involved in PR activation, we created a series of p6* mutants by making substitutions for conse...

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Detalles Bibliográficos
Autores principales: Yu, Fu-Hsien, Huang, Kuo-Jung, Wang, Chin-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794111/
https://www.ncbi.nlm.nih.gov/pubmed/35085286
http://dx.doi.org/10.1371/journal.pone.0262477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794111/
https://www.ncbi.nlm.nih.gov/pubmed/35085286
http://dx.doi.org/10.1371/journal.pone.0262477

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