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Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity
A transframe region within HIV-1 Gag-Pol (referred to as p6* or p6pol), directly linked to the protease (PR) N-terminus, plays a pivotal role in modulating PR activation. To identify specific p6* residues involved in PR activation, we created a series of p6* mutants by making substitutions for conse...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794111/ https://www.ncbi.nlm.nih.gov/pubmed/35085286 http://dx.doi.org/10.1371/journal.pone.0262477 |