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Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation

Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SETD8 and NSD2 inhibited the senescence program in c...

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Detalles Bibliográficos
Autores principales:	Igata, Tomoka, Tanaka, Hiroshi, Etoh, Kan, Hong, Seonghyeon, Tani, Naoki, Koga, Tomoaki, Nakao, Mitsuyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794122/ https://www.ncbi.nlm.nih.gov/pubmed/35085309 http://dx.doi.org/10.1371/journal.pone.0262488

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