Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

In the course of experiments aimed at deciphering the inhibition mechanism of mycophenolic acid and ribavirin in hepatitis C virus (HCV) infection, we observed an inhibitory effect of the nucleoside guanosine (Gua). Here, we report that Gua, and not the other standard nucleosides, inhibits HCV repli...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabariegos, Rosario, Ortega-Prieto, Ana María, Díaz-Martínez, Luis, Grande-Pérez, Ana, García Crespo, Carlos, Gallego, Isabel, de Ávila, Ana I., Albentosa-González, Laura, Soria, María Eugenia, Gastaminza, Pablo, Domingo, Esteban, Perales, Celia, Mas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794218/
https://www.ncbi.nlm.nih.gov/pubmed/35085375
http://dx.doi.org/10.1371/journal.ppat.1010210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794218/
https://www.ncbi.nlm.nih.gov/pubmed/35085375
http://dx.doi.org/10.1371/journal.ppat.1010210

Ejemplares similares