Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

In the course of experiments aimed at deciphering the inhibition mechanism of mycophenolic acid and ribavirin in hepatitis C virus (HCV) infection, we observed an inhibitory effect of the nucleoside guanosine (Gua). Here, we report that Gua, and not the other standard nucleosides, inhibits HCV repli...

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Detalles Bibliográficos
Autores principales: Sabariegos, Rosario, Ortega-Prieto, Ana María, Díaz-Martínez, Luis, Grande-Pérez, Ana, García Crespo, Carlos, Gallego, Isabel, de Ávila, Ana I., Albentosa-González, Laura, Soria, María Eugenia, Gastaminza, Pablo, Domingo, Esteban, Perales, Celia, Mas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794218/
https://www.ncbi.nlm.nih.gov/pubmed/35085375
http://dx.doi.org/10.1371/journal.ppat.1010210

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