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Data-driven modeling predicts gene regulatory network dynamics during the differentiation of multipotential hematopoietic progenitors
Cellular differentiation during hematopoiesis is guided by gene regulatory networks (GRNs) comprising transcription factors (TFs) and the effectors of cytokine signaling. Based largely on analyses conducted at steady state, these GRNs are thought to be organized as a hierarchy of bistable switches,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794271/ https://www.ncbi.nlm.nih.gov/pubmed/35030198 http://dx.doi.org/10.1371/journal.pcbi.1009779 |