The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation

Kasugamycin (KSG) is an aminoglycoside antibiotic widely used in agriculture and exhibits considerable medical potential. Previous studies suggested that KSG interferes with translation by blocking binding of canonical messenger RNA (mRNA) and initiator transfer tRNA (tRNA) to the small ribosomal su...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Aleksashin, Nikolay A., Klepacki, Dorota, Anderson, Caleb, Vázquez-Laslop, Nora, Gross, Carol A., Mankin, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794815/
https://www.ncbi.nlm.nih.gov/pubmed/35064089
http://dx.doi.org/10.1073/pnas.2118553119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794815/
https://www.ncbi.nlm.nih.gov/pubmed/35064089
http://dx.doi.org/10.1073/pnas.2118553119

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