Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack

Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA), colorectal cancer, and breast cancer are coated with transglutaminase-2 (TGM2)–de...

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Detalles Bibliográficos
Autores principales: Wang, Zhikai, Moresco, Philip, Yan, Ran, Li, Jiayun, Gao, Ya, Biasci, Daniele, Yao, Min, Pearson, Jordan, Hechtman, Jaclyn F., Janowitz, Tobias, Zaidi, Raza M., Weiss, Matthew J., Fearon, Douglas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794816/
https://www.ncbi.nlm.nih.gov/pubmed/35046049
http://dx.doi.org/10.1073/pnas.2119463119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794816/
https://www.ncbi.nlm.nih.gov/pubmed/35046049
http://dx.doi.org/10.1073/pnas.2119463119

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