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Ca(2+) leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle
Mammals rely on nonshivering thermogenesis (NST) from skeletal muscle so that cold temperatures can be tolerated. NST results from activity of the sarcoplasmic reticulum (SR) Ca(2+) pump in skeletal muscle, but the mechanisms that regulate this activity are unknown. Here, we develop a single-fiber a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794839/ https://www.ncbi.nlm.nih.gov/pubmed/35046046 http://dx.doi.org/10.1073/pnas.2119203119 |