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Ca(2+) leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

Mammals rely on nonshivering thermogenesis (NST) from skeletal muscle so that cold temperatures can be tolerated. NST results from activity of the sarcoplasmic reticulum (SR) Ca(2+) pump in skeletal muscle, but the mechanisms that regulate this activity are unknown. Here, we develop a single-fiber a...

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Detalles Bibliográficos
Autores principales:	Meizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J., Launikonis, Bradley S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794839/ https://www.ncbi.nlm.nih.gov/pubmed/35046046 http://dx.doi.org/10.1073/pnas.2119203119

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